While necroptosis-associated hepatic cytokine microenvironment favors development of intrahepatic cholangiocarcinoma, a apoptotic environment give rise to hepatocellular carcinoma. Epigenetic regulation of Tbx3 and Prdm5 are major drivers of lineage decisions in liver cancer.

(Seehawer M et al. – Nature, 12 September 2018)
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