This study included 363 resected HCC specimens analyzed with whole exome sequencing, RNA-seq, miRNA, methylation and proteomics. It confirmed previous findings in terms of key HCC drivers, in addition to reporting a novel subclass characterized by metabolic de-regulation (i.e., IDH). It represents the most comprehensive integrative genomic analysis of HCC to date.
(Ally A et al. – Cell., 15 June 2017)