Utilizing an mTOR-driven hepatocellular carcinoma mouse model, the authors identified LHPP as a histidine phosphatase (a process involved in the post-translational modification of proteins) with novel tumour suppressor activity. Hepatic expression of LHPP decreases tumor burden and patients with low levels of LHPP have a reduced overall survival.

(Hindupur SK et al. – Nature., 29 March 2018)

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