In this study, the authors identified recurrent mutations in cirrhotic and non-cirrhotic liver tissue collected from HCC or transplant patients. Mutation profiles were distinct from known aberrations in HCC, however, number of mutations and clones correlated with liver damage and fibrosis stage. As indicated by in vivo models of chronic liver injury, loss of function in Arid1a, Kmt2d, or Pkd1 associated with a fitness advantage in liver regeneration.
(Zhu M et al. – Cell., 18 April 2019)