As opposed to DNA modifications, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. Methyltransferase-like 3 (METTL3), a major RNA N6-adenosine methyltransferase, is frequently up-regulated in human HCCs and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. The findings highlight an important mechanism of epigenetic alteration in liver carcinogenesis.
(Chen M et al. – Hepatology, 24 November 2017)