The authors describe specific patterns in cell-free DNA fragments with ends at certain genomic coordinates that correlate with their cell of origin, in this case hepatocellular carcinoma and liver tissue in general. These tumour-associated plasma DNA end coordinates have a higher prevalence than somatic mutations and might serve as a cost-effective cancer signature in plasma.

(Jiang P et al. – Proceedings of the National Academy of Sciences of the United States of America, 29 October 2018)

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