The study characterized genomic alterations of a known carcinogen-induced (diethylnitrosamine) mouse model of HCC using whole exome sequencing. Authors identified Hras, Braf, Egfr and Apc as oncogenic drivers. Unlike human HCC, the model has high exome-wide SNV burden with strong inter-tumoral diversity, and a paucity of copy number alterations, as expected for a mutagen-inducing model, but yet reflecting histological similarities to human HCC.
(Connor F et al. – Journal of Hepatology, 26 June 2018)