Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. However, authors found that the soluble fiber inulin induced hepatocellular carcinoma (HCC) in dysbiotic mice. This model was transmissible to healthy mice by an inulin-enriched high fat diet inducing dysbiosis and HCC. Inhibition of fermentation reduced intestinal SCFA and prevented HCC. Authors conclude that fermentable fiber should be approached with great caution as it may increase risk of HCC.
(Singh V et al. – Cell., October 2018)