A first study in 41 patients showing evidence of local immune activation in tumour-infiltrating leucocytes and activated chemotactic pathways after internal irradiation, using mass cytometry and NGS. Potential biomarkers of response to treatment were also identified. The findings support testing the combination of external or internal irradiation with checkpoint inhibitors in HCC, and illustrate the value of correlative studies for clinical trial design.
(Chew V, et al. – Gut., 13 February 2018)