This basic (in mice) and translational (in human) study showed that activation of Wnt/b-catenin pathway induced by CTNNB1mutations in hepatocellular carcinoma lead to the accumulation of choline in malignant hepatocytes. Interestingly, HCCs with mutation of CTNNB1were strongly positive in 18 fluorocholine PET/CT scan but negative in 18 FDG PET/CT scan.

(Gougelet A et al. – Gastroenterology, June 2019)

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