Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common types of liver cancer. More rare are combined HCC-ICC tumors, which simultaneously present both histologies within the same tumor. As shown by Xue et al. combined HCC-ICC tumors represent a distinct liver tumor subtype, with different clinical and molecular features, including higher expression of Nestin, which could be used as a biomarker for their detection. Further studies will help identify specific therapies for this novel subtype of liver cancer.

(Ruidong Xue et al. – Cancer Cell, 23 May 2019)

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