Authors developed a classifier to identify HCC patients from controls at risk using an immunofluorescence-based method enriching for glypican-3 and cytokeratin expressing cells (iChip) to isolate circulating epithelial cells from the blood of patients with chronic liver disease and HCC. The cross-validated classifier provided separation between controls and HCC samples with a preliminary sensitivity of 85% at a specificity of 95%.

(Bhan I et al. – Gastroeneterology, December 2018)

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