A high-throughput microfluidic CTC-iChip allows for effective enrichment of CTCs in patients with HCC. CTC scores correlated with disease stage and declines in treated patients. Digital RNA quantitation in blood emerges as a sensitive and specific CTC readout, and expands the portfolio of liquid biopsy applications.
(Kalinich M et al. – Proceedings of the National Academy of Sciences of the United States of America, January 2017)