An enzyme in the folate cycle, methylenetetrahydrofolate dehydrogenase 1–like (MTHFD1L plays an essential role in support of cancer growth and contributes to the production and accumulation of NADPH to levels sufficient to combat oxidative stress in cancer cells.  The elevation of oxidative stress through MTHFD1L knockdown or the use of methotrexate (an antifolate drug) sensitizes cancer cells to sorafenib in HCC.

(Derek Lee et al. – The Journal of Clinical Investigation, 1 May 2017)

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